Alcohol dehydrogenase 1C (ADH1C) polymorphism is significantly associated with kidney function status in Nusa Tenggara Timur ethnicity: A cross-sectional study

Excessive alcohol consumption is harmful to many human organs, but the association with kidney function still controversial. The disagreement in findings might be caused by ADH1C polymorphism's influence on metabolism rate. This study aims determine correlation between polymorphism and status Nusa Tenggara Timur (NTT) ethnicity, a population highly prevalent Indonesia. We conducted cross-sectional of 76 subjects, who are natives NTT, genotyping extracted DNA for was done polymerase chain reaction-restriction fragment length (PCR-RFLP) using restriction endonuclease SspI. Kidney defined serum urea level estimated glomerular filtration rate (eGFR) that had been categorized according percentiles. allele analyzed chi-square tests. genotype NTT ethnicity ADH1C*1/*2 (51.3%), ADH1C*2/*2 (47.4%), ADH1C*1/*1 (1.3%). results showed ADH1C*2 (73.03%) ADH1C*1 (26.97%) allele. There significant eGFR among (p=0.005) when at 25th percentile (74.75 mL/minute/1.73m2). However, we found no associations 50th (p=0.571) 75th (p=0.335) odds ratio shows having escalates probability declining 6.620 times compared (95% CI: 1.539-28.478), after adjusted smoking behavior. (p=0.123, 0.421, 0.335). majority have genotype. Populations higher below 74.75 mL/minute/1.73m2 than those levels.